While researching Palmitoyl Tripeptide-3, which I talked about Monday, I found research on a peptide that appears even more exciting at first glance.
Palmitoyl Tripeptide-1 (PTri-1, Tradenames Trylagen and Aldenine) has been validated with in vitro, as well as in vivo studies using human subjects. The results are impressive. In vitro tests using reconstituted human skin, yielded increases in collagen I and collagen IV synthesis of 128 and 81% respectively after just 15 days. Collagen III synthesis (the most abundant type of collagen in young skin) tripled!
Tissue sectioning of the treated skin tissue examined under an electron microscope revealed that the collagen fibers were significantly more uniform and better organized, as they would be in young skin. This effect results in fuller more supple skin.
In addition, in vitro studies showed that PTri-1 even inhibits the body’s anticollagenase activity. Anticollagenase enzymes are one of the factors that cause collagen degradation as we age. Anticollagenase MMP-2 and MMP-3 were inhibited 74 and 57% respectively.
In vivo, twice daily application of Trylagen by 20 female volunteers aged 35 to 55 for 30 days resulted in a 29% decrease in wrinkle depth as measured by 3D optical equipment.
I’m on a quest for the best. Please check back next time for an update.
Tags: Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-3, collagen synthesis
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